Grupa za molekularnu biologiju
ponedjeljak, 9 srpnja 2007. godine u 18.00 sati predavaonica B02 (MB1)
Prirodoslovno-matematièkog fakulteta, Rooseveltov trg 6, Zagreb

Aline V. Probst, PhD
Laboratory of Nuclear Dynamics and Genome Plasticity
Institut Curie, Paris, France

Organization and establishment of heterochromatin

Constitutive heterochromatin in mammals is essentially found at centromeres, which are key chromosomal elements that ensure proper chromosome segregation. These regions are considered to be epigenetically defined, given that it is not sequence composition but chromatin organization that determines centromere function. How such an epigenetically defined domain, like the centromere, can be established during development and maintained during somatic cell life are fundamental questions. I will discuss our recent knowledge on centromeric heterochromatin organization in the mouse and how higher-order organization of this domain can be maintained during DNA replication. To gain insight into the establishment of centromeric heterochromatin we have used mouse early pre-implantation development as model system. Our results reveal the dynamic re-organization of the centromere that occurs during the first cell cycle of the fertilized egg and the requirement of the nuclear histone chaperone CAF-1 for proper heterochromatin organization during embryonic development.

Predsjednica HGD-a:
Prof.dr.sc. Jasna Franekiæ, PBF

Koordinatori predavanja:
Dr. sc. Ksenija Zahradka, zn. sur., IRB
Dr. sc. Krešimir Gjuraèiæ, GSK Research Centre Zagreb Ltd.